Highlight

• Covalent ACE2 vesicles neutralized SARS-CoV-2 by irreversible binding to spike receptor

• An inhalable formulation of vesicles showed an ∼20-fold-improved lung retention

• A single dose of vesicles inhibited SARS-CoV-2 infection and improved animal survival

• A lyophilized formulation of vesicles enabled long-term storage for more than 1 month

Title

Antiviral covalent ACE2 vesicle spray

Authors

Qian-Fang Meng, Yu Han,Yu Liu, Pan Pan, Rong-Chang Chen, Heng Zhang, Lang Rao

Journal Information

Cell Biomaterials (2025)

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