Highlights

• Lower levels and faster decline rates of FA are more correlated with tau than Aβ

• Lower FA levels predict faster increase rates of WMH but not vice versa

• Lower FA levels fully explain Aβ-related and partially mediate age-related WMH burden

• Microstructural degeneration precedes macrostructural WM degeneration in aging and AD

Title

White matter fractional anisotropy decreases precede hyperintensities in Alzheimer's disease

Authors

Pan Sun, Zhengbo He, Erwei Chu, Xiang Fan, Yue Cai, Guoyu Lan, Lin Liu, Dai Shi, Li Liang, Jie Yang, Anqi Li, Yalin Zhu, Xin Zhou, Lili Fang, Yiying Wang, Laihong Zhang, Zhen Liu, Ting Ma, Alzheimer's Disease Neuroimaging Initiative, Guanxun Cheng, Linsen Xu, Tengfei Guo

Journal Information

Cell Reports Medicine (2025)

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