Abstract

Targeted protein degradation (TPD) is a groundbreaking approach in molecular therapeutics, enabling the selective elimination of specific proteins by leveraging the cell's own degradation machinery. In November 2024, the SMART Symposium titled “Targeted Protein Degradation: from basic science to therapeutic applications” offered a comprehensive communication on the cutting-edge chemical strategies and emerging clinical applications in this rapidly advancing field.

Title

Targeted Protein Degradation: From Basic Science to Therapeutic Applications

Authors

Rongfeng Zhu, Xiaoyu Tang, Heng Zhang

Journal Information

ACS Chemical Biology (2025)

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