Highlights

Point mutations of MmTMC1/2 are localized to the plasma membrane of heterologous cells

CRISPRi promotes HsTMC1/2 trafficking to the plasma membrane of heterologous cells

HsTMC1 and HsTMC2 can be activated by mechanical stimuli

HsTMC1 and HsTMC2 are pore-forming subunits of mechanogated ion channels

Title

Human TMC1 and TMC2 are mechanically gated ion channels

Authors

Songdi Fu, Xueqi Pan, Mingshun Lu, Jianying Dong, Zhiqiang Yan

Journal Information

Neuron (2024)

DOI

https://10.1016/j.neuron.2024.11.009

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