CryoSeek identification of glycofibrils with diverse compositions and structural assemblies-Shenzhen Bay Laboratory

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Highlights• Five previously uncharacterized glycofibrils are identified and structurally analyzed• The glycofibrils exhibit diverse compositions and distinct structural assemblies• TLP-2 and TLP-4a/b are glycan-coated linear strands of di- and tetra-peptide repeats• TLP-0 is a unique glycofibril composed entirely of glycans, with no protein contentTitleCryoSeek identification of glycofibril...

Highlights

• Five previously uncharacterized glycofibrils are identified and structurally analyzed

• The glycofibrils exhibit diverse compositions and distinct structural assemblies

• TLP-2 and TLP-4a/b are glycan-coated linear strands of di- and tetra-peptide repeats

• TLP-0 is a unique glycofibril composed entirely of glycans, with no protein content

Title

CryoSeek identification of glycofibrils with diverse compositions and structural assemblies

Authors

Zhangqiang Li, Tongtong Wang, Yitong Sun, Kui Xu, Wenze Huang, Qiangfeng Cliff Zhang, Chuangye Yan, Mingxu Hu, Nieng Yan

Journal Information

Cell Chemical Biology (2026)

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