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地址:深圳市光明区光侨路高科创新中心
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Bo Zhang, Ph.D./
Institute/Center

Institute of Neurological and Psychiatric Disorders

Email

zbo@szbl.ac.cn


Research Direction

Neuroscience,Physiology,Molecular Biology

Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2020 - Present
Shenzhen Bay Laboratory

Junior Principal Investigator

2019 - Present
Peking University Shenzhen Graduate School

Principle Investigator

2017 - 2018
Stanford University

Basic Research Scientist

2011 - 2017
Stanford University & HHMI

(Postdoc) Research Associate

2011
Peking University

PhD

2001 - 2005
MinZu University of China

B.S.

Research Areas

The human brain consists of more than 100 billion neurons, which process and transmits information at specialized junctions called synapses. Our laboratory is interested in understanding the molecular basis of the formation and function of synapses and exploring the mechanisms underlying the impairments in synaptic function that are observed in neurodevelopmental and neurodegenerative disorders. In pursuing those questions, our laboratory will utilize an interdisciplinary approach that spans from in vitro studies to animal behavior assessments and includes dual-patch recording in the acute slice, animal behavior, stereotaxic injection of virus for gene manipulation and for functional circuit tracing, optogenetics, molecules biology, mouse genetics.

Highlights

Bo Zhang is a Principle investigator in the Institute of neurological and neuropsychiatric disorders at Shenzhen Bay laboratory. His lab is interested in understanding the molecular basis of the formation and function of synapses and exploring the mechanisms underlying the impairments in synaptic function that are observed in neurodevelopmental and neurodegenerative disorders. He received his PhD in Physiology from the Peking University under the mentorship of Zhuan Zhou. After a postdoc training in Stanford University School of Medicine/Howard Hughes Medicine Institute with Thomas Südhof, he joined the faculty at the Peking University Shenzhen graduate school in January 2019. In March 2019, he joined Shenzhen Bay laboratory. His lab is currently supported by grants from Shenzhen-Hong Kong Institute of Brain Science (2019), the General Project of Guangdong Natural Science Foundation (2019), the General Program of NSFC (2021-2014), and NSFC Excellent Young Scholars Fund (2021-2023).

Honors
2020 NSFC Excellent Young Scholars Fund
2019 Guangdong Pearl River Talent Program (Overseas Top Young Talent)
2019 Peacock Program for Overseas High-Level Talents
Media
Recruitment
Papers

(* first author; # Corresponding author)

1: Qin, L*, Liu, Z.*, Guo, S., Han, Y., Wang, X., Ren, W., Chen, J., Zhen, H., Nie, C., Xing, K., Chen, T., Südhof TC*, Sun, Y.*,Zhang, B*. (2024). Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number.Molecular Psychiatry.

2: Lloyd, B.A., Han, Y., Roth, R.,Zhang, B., Aoto, J*. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.Nature Communications. 14, 4706.

3: Zhu, F.#, Liu, L.#, Li, J.#, Liu, B., Wang, Q., Jiao R., Xu, Y., Wang, L., Sun, S., Sun, X., Younus, M., Wang, C., Hokfel, T.,Zhang, B.*, Gu, H. *, Xu, Z. *, Zhou, Z. *. (2022). Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons.Cell Reports. 40(7), 16 August 2022, 111199.

4: Han, Y#, Cao, R#, Qin, L., Chen, L., Tang, A., *, Südhof, TC*,Zhang, B*. (2022) Neuroligin-3 confines AMPA-receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses.Science Advances. 8(24):eabo4173.

5: Qin, L., Guo, S., Han, Y., Wang, X.,Zhang, B*. (2020) Functional mosaic organization of neuroligins in neuronal circuits.Cellular and Molecular Life Sciences. 77, 3117-3127.

6:Zhang, B.*,Gokce, O., Hale, D., Brose, N., Südhof, TC. (2018) Autism-associated Neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.Journal of Experimental Medicine. 215 (6): 1543-1553

7:Zhang, B.*,Seigneur, E., Wei, P., Gokce, O., Morgan, J., Südhof, TC. (2017) Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held.Molecular Psychiatry. 22, 1483–1491.[F1000 recommended]

8:Zhang, B.*, Südhof, TC. (2016). Neuroligins are selectively essential for NMDA-receptor signaling in cerebellar stellate interneurons.J.Neurosci. 36(35):9070-9083.[F1000 recommended].

9:Zhang, B.#, Chen, L. #, Maxeiner, S., Lee, S., Gokce, O., Südhof, TC*. (2015) Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.Neuron. 87(4):781-96.