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地址：深圳市光明区光侨路高科创新中心
电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
Gui-Wei He, Ph.D./
Institute/Center
Institute of Infectious Diseases
Email
hegw(at)szbl.ac.cn
Research Direction
Cancer Biology,Neuroscience,Medicine and Translational Research
Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2023 - Present
Shenzhen Bay laboratory
Junior Principle Investigator
2019 - 2022
Hubrecht Institute
Postdoc
2012 - 2019
Friedrich-Alexander-Universität Erlangen-Nürnberg
PhD, Postdoc
2004 - 2011
Jinan University, Guangzhou
Bachelor of Science, Master of Science
Research Areas
We are interested in understanding the fundamental biological principles underlying tissue development and disease, particularly infectious disease and cancer. We aim to establish the most advanced organoid culture systems to model these human pathologies and to reveal mechanisms that prevent or drive disease, with the ultimate goals of identifying novel therapeutic strategies.
Highlights
Dr. He Gui-Wei received his PhD degree withsumma cum laudefrom the University of Erlangen-Nuremberg in Germany in 2018. Then Dr. He joined Professor Hans Clevers laboratory at the Hubrecht Institute, where he developed a next-generation human intestinal organoid model and used this new model system to study human intestinal development and diseases. Dr. He's studies were published in high-profile journals, includingCell Stem Cell, GutandJournal of Experimental Medicine.
In this study, we establish an optimized human intestinal organoid model and discover the mechanisms of interleukin-22-dependent Paneth cell formation.
Honors
2017 Chinese Government Award for Outstanding Self-financed Students Abroad
Recruitment
Papers
1.He, G. W.#; Lin, L.#; DeMartino, J.; Zheng, X.; Staliarova, N.; Dayton, T.; Begthel, H.; Wetering, W.; Bodewes, E.; Zon, J. E.; Tans, S.; Lopez-Iglesias, C.; Peters, P. J.; Wu, W.; Kotlarz, D.; Klein, C.; Margaritis, T.; Holstege, F.; Clevers, H., Optimized human intestinal organoid model reveals interleukin-22-dependency of Paneth cell formation.Cell Stem Cell.2022.
2.He, G. W.; Gunther, C.; Thonn, V.; Yu, Y. Q.; Martini, E.; Buchen, B.; Neurath, M. F.; Sturzl, M.; Becker, C., Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice.J Exp Med2017,214(6), 1655-1662.
3.He, G. W.#; Gunther, C.#; Kremer, A. E.; Thonn, V.; Amann, K.; Poremba, C.; Neurath, M. F.; Wirtz, S.; Becker, C., PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.Gut2017,66(4), 716-723.
4. Gunther, C.;He, G. W.; Kremer, A. E.; Murphy, J. M.; Petrie, E. J.; Amann, K.; Vandenabeele, P.; Linkermann, A.; Poremba, C.; Schleicher, U.; Dewitz, C.; Krautwald, S.; Neurath, M. F.; Becker, C.; Wirtz, S., The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.J Clin Invest2016,126(11), 4346-4360.
5. Driehuis, E.; Kolders, S.; Spelier, S.; Lohmussaar, K.; Willems, S. M.; Devriese, L. A.; de Bree, R.; de Ruiter, E. J.; Korving, J.; Begthel, H.; van Es, J. H.; Geurts, V.;He, G. W.; van Jaarsveld, R. H.; Oka, R.; Muraro, M. J.; Vivie, J.; Zandvliet, M.; Hendrickx, A. P. A.; Iakobachvili, N.; Sridevi, P.; Kranenburg, O.; van Boxtel, R.; Kops, G.; Tuveson, D. A.; Peters, P. J.; van Oudenaarden, A.; Clevers, H., Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.Cancer Discov2019,9(7), 852-871.
Contact
Address: Gaoke Innovation Center,Guangming District, Shenzhen
Phone: +86-755-86967710
Email: webmaster@szbl.ac.cn
Postal Code: 518132
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