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电话：+86-755-86967710
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电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
Haoyue Zhang, Ph.D./
Institute/Center
Institute of Molecular Physiology
Email
zhang_adam@szbl.ac.cn
Research Direction
Molecular biology,Cell Biology
Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2021- Present
Shenzhen Bay Laboratory
Junior Principal Investigator
2016 - 2021
The Children's Hospital of Philadelphia
Postdoc Fellow
2011 - 2016
University of Maryland College Park
Ph.D.
2007 - 2011
Tongji University
B.S.
Research Areas
Epigenetics, genomics, 3D genomics, transcription regulation and disease, mitosis, aging.
Highlights
• Established an in-vitro induction and differentiation system for vascular smooth muscle cells from premature aging HGPS patients.
• Revealed the molecular mechanism of HGPS smooth muscle cell death, providing noval therapeutic potential for the treatment of HGPS patients.
• Revealed the process of chromatin 3D structural reconfiguration during the mitosis to G1 phase transition; uncovered the dynamic process of post-mitotic chromatin recruitment of the architectural protein CTCF and cohesin ring complex; provides noval supports for the regulation role of loop extrusion model in post-mitotic chromatin 3D structural reconfiguration.
• Uncovered the relationship between chromatin 3D structural reconfiguration and transcription reactivation after mitosis.
• Uncovered the role of architecture protein CTCF in the reconfiguration of chromatin 3D structure after mitosis.
Has been publishing in prestigious journals includingNature,PNAS,Aging Celletc.
Reestablishment of chromatin A/B compartments during the mitosis to G1 phase transition
Honors
2017 Charles A. Caramello Distinguished Dissertation Award, University of Maryland College Park
2014 MOCB Travel Award, University of Maryland College Park
2014 BISI Merit Student Award, University of Maryland College Park
2013 Best Poster Presentation Award. University of Maryland, School of Medicine
2011 Dean' s Fellowship, University of Maryland College Park
2011 Best Thesis Award, Tongji University
2010 China National Scholarship, Ministry of Education, China
2009 First Class Scholarship, Tongji University
2009 Shanghai Scholarship, Shanghai Education Commission, China
Media
Recruitment
Papers
Preprints:
Aboreden, N. G., H. Zhao, F. Shan, F. Liu,H. Zhang*, and G. A. Blobel*. "Cis-Regulatory Chromatin Contacts Form De Novo in the Absence of Loop Extrusion." bioRxiv (Feb 8 2025). https://dx.doi.org/10.1101/2025.01.12.632634.
Primary publications:
Zhao, H., L. Shu, S. Qin, F. Lyu, F. Liu, E. Lin, S. Xia, B. Wang, M. Wang, F. Shan, Y. Lin, L. Zhang, Y. Gu, G. A. Blobel, K. Huang*, andH. Zhang*."Extensive Mutual Influences of Smc Complexes Shape 3D Genome Folding."Nature(Feb 26 2025).https://dx.doi.org/10.1038/s41586-025-08638-3.
Zhao, H., Y. Lin, E. Lin, F. Liu, L. Shu, D. Jing, B. Wang, M. Wang, F. Shan, L. Zhang, J. C. Lam, S. C. Midla, B. M. Giardine, C. A. Keller, R. C. Hardison, G. A. Blobel*, andH. Zhang*."Genome Folding Principles Uncovered in Condensin-Depleted Mitotic Chromosomes."Nat Genet(May 27 2024). https://dx.doi.org/10.1038/s41588-024-01759-x.
Zhang, H*., J. Lam, D. Zhang, Y. Lan, M. W. Vermunt, C. A. Keller, B. Giardine, R. C. Hardison, and G. A. Blobel. "Ctcf and Transcription Influence Chromatin Structure Re-Configuration after Mitosis."Nat Commun12, no. 1 (Aug 27 2021): 5157. https://dx.doi.org/10.1038/s41467-021-25418-5.
Zhang, H., D. J. Emerson, T. G. Gilgenast, K. R. Titus, Y. Lan, P. Huang, D. Zhang, H. Wang, C. A. Keller, B. Giardine, R. C. Hardison, J. E. Phillips-Cremins, and G. A. Blobel. "Chromatin Structure Dynamics During the Mitosis-to-G1 Phase Transition."Nature576, no. 7785 (Dec 2019): 158-62. https://dx.doi.org/10.1038/s41586-019-1778-y.
Zhang, H., L. Sun, K. Wang, D. Wu, M. Trappio, C. Witting, and K. Cao. "Loss of H3k9me3 Correlates with Atm Activation and Histone H2ax Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome."PLoS One11, no. 12 (2016): e0167454. https://dx.doi.org/10.1371/journal.pone.0167454.
Zhang, H., Z. M. Xiong, and K. Cao. "Mechanisms Controlling the Smooth Muscle Cell Death in Progeria Via Down-Regulation of Poly(Adp-Ribose) Polymerase 1."Proc Natl Acad Sci U S A111, no. 22 (Jun 3 2014): E2261-70. https://dx.doi.org/10.1073/pnas.1320843111.
Review Articles:
Zhang, H*., and G. A. Blobel. "Genome Folding Dynamics During the M-to-G1-Phase Transition."Curr Opin Genet Dev80 (Jun 2023): 102036.https://dx.doi.org/10.1016/j.gde.2023.102036.
Zhang, H., J. E. Kieckhaefer, and K. Cao. "Mouse Models of Laminopathies."Aging Cell12, no. 1 (Feb 2013): 2-10. https://dx.doi.org/10.1111/acel.12021.
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