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地址:深圳市光明区光侨路高科创新中心
电话:+86-755-86967710
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Lei Zhou, Ph.D./
Institute/Center

Institute of Molecular Physiology

Email

zhoulei@szbl.ac.cn


Research Direction

Biophysics,Computational Biology,Neuroscience

Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2020 - Present
Shenzhen Bay Laboratory

Senior Principal Investigator

2008 - 2020
Medical College of Virginia

Associate Professor

2000 - 2008
Columbia University

Postdoc

2000
University of Wisconsin

PhD

1992 - 1994
Chinese Academy of Medical Sciences

MSc

1992
Nankai University

Bachelor

Honors
1991 Shen-Shou Chun Experimental Physics Prize, Nankai University, China
2000 18th Jerzy E. Rose Neuroscience Award for original and significant research in the neuroscience, UW - Madison
Media
Recruitment
Papers

1. Zhang X, Wu R, Liu Q,Zhou L*. Interfacial water molecules contribute to antibody binding to the receptor-binding domain of SARS-CoV-2 spike protein.J Biomol Struct Dyn.2023 Apr 12:1-10.

2. Yao R, Hou J, Zhang X, Li Y, Lai J, Wu Q, Liu Q,Zhou L*. Targeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen.Photochem Photobiol Sci.2023 Feb 8:1-18.

3. Shah N,Zhou L*. Regulation of Ion Channel Function by Gas Molecules.Adv Exp Med Biol.2021;1349:139-164. PMID: 35138614 Review.

4. Wei F, Wang Q, Han J, Goswamee P, Gupta A, McQuiston AR, Liu Q,Zhou L*. Photodynamic modification of native HCN channels expressed in thalamocortical neurons.ACS Chem Neurosci.2020 Feb 20; 11(6):851-863.

5. Idikuda V, Gao W, Grant K, Su Z, Liu Q, andZhou L*.State-dependent binding of cAMP to closed, inactivated, and open sea urchin HCN channels.Journal of General Physiology.2019 Feb 4;151(2):200-213. PMID: 30541772 Dec 12.

6. Idikuda V, Gao W, Grant K, Su Z, Liu Q, andZhou L*.Singlet oxygen modification abolishes voltage-dependent inactivation in sea-urchin hyperpolarization-activated cyclic nucleotide-gated (spHCN) channel.Journal of General Physiology.2018 Sep 3;150(9):1273-1286.018.

7. Zhu M, Idikuda V, Wang J, Wei F, Kumar V, Shah N, Waite CB, Liu Q,Zhou L*. Shank3-deficient thalamocortical neurons show HCN channelopathy and alterations in intrinsic electrical properties.Journal of Physiology.2018 Apr 1;596(7):1259-1276.

8. Liu C, Xie C, Grant KL, Su Z, Gao W, Liu Q,Zhou L*.Determine the unitary conductance of HCN channels by a channel counting method based on patch-clamp fluorometry.Journal of General Physiology.2016 Jul;148(1):65-76.

9. Gao W, Su Z, Liu Q,Zhou L*.State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen.Journal of General Physiology.2014 May;143(5):633-44.

10.Zhou L*, Liu Q. Aligning experimental and theoretical anisotropic B-factors: water models, normal-mode analysis methods, and metrics.Journal of Physical Chemistry B.2014 Apr 17;118(15):4069-79.