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地址:深圳市光明区光侨路高科创新中心
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Lin Deng, Ph.D./
Institute/Center

Institute of Molecular Physiology

Email

denglin(at)szbl.ac.cn


Research Direction

Cell Biology,Cancer Biology,Biochemistry

Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2020 - Present
Shenzhen Bay Laboratory

Junior Principal Investigator

2015-2020
Harvard Medical School & Dana-Farber Cancer Institute & Howard Hughes Medical Institute

Research Fellow

2010 - 2015
Dartmouth College

Ph.D.

2008 - 2010
Northwest Agriculture & Forestry University

M.S.

2004 - 2008
Northwest Agriculture & Forestry University

B. S.

Research Areas

The Deng laboratory is interested in cell cycle regulation and genome instability. We use a combination of cutting-edge techniques such as in vitro  biochemical reconstitution, genome engineering, high throughput live-cell imaging, genome sequencing and so forth, to address how cells coordinate growth and division under normal and pathological conditions such as cancer.



Highlights

Dr. Lin Deng has a long-standing interest in cell cycle regulation and genome instability. He obtained his Ph.D. in Biochemistry from Dartmouth College in U.S., supervised by Dr. James Moseley. His Ph.D. work dissected the signaling pathways for G2/M transition and discovered many novel factors and sub-cellular structures that regulate cell growth and division. Dr. Deng received his postdoc training at Harvard Medical School and Dana Farber Cancer Institute, jointly supervised by Dr. David Pellman and Joahnnes Walter. His postdoc research revealed novel mechanisms of genome instability induced by DNA replication stress and cell cycle defects.

Dr. Deng’s research has been published in peer-reviewed journals such as  Molecular Cell, Current Biology, Molecular Biology of the Cell, Molecular and Cellular Biology, and so forth. These works have been recognized by several awards including The International Youth Friend of Shenzhen, China (2017), E. Lucile Smith Award for Excellence in Biochemistry, Dartmouth Medical School (2015), Chinese Government Award for Outstanding Students Abroad (2014), and John H. Copenhaver, Jr. and William H. Thomas, MD 1952 Fellow, Dartmouth College (2014).


Mechanism of genome instability caused by premature mitosis


Honors
2014 - 2015 John H. Copenhaver, Jr. and William H. Thomas, MD 1952 Fellow, Dartmouth College
2015 E. Lucile Smith Award for Excellence in Biochemistry, Dartmouth Medical School
2015 Chinese Government Award for Outstanding Students Abroad
2017 The International Youth Friend of Shenzhen City, China
2020 Oversea High-caliber Personnel, Shenzhen, China
Media
Recruitment
Papers

1.Deng, L., Wu, R.A., Sonneville, R., Kochenova, O.V., Labib, K., Pellman, D., and Walter, J.C. (2019). Mitotic CDK promotes replisome disassembly, fork collapse, and complex DNA rearrangements.Molecular Cell, 73(5):915-929.e6. PMID: 30849395.

2.Deng, L., Lee, M.E. Schutt K.L., and Moseley, J.B. (2017). Phosphatases generate signal specificity downstream of Ssp1 kinase in fission yeast.Molecular and Cellular Biology, 37:e00494-16.doi: 10.1128/MCB.00494-16. PMID: 28223368.

3.Deng, L., Baldissard, S., Kettenbach, A.N., Gerber, S.A., and Moseley, J.B. (2014). Dueling kinases regulate cell size at division through the SAD kinase Cdr2.Current Biology24, 428-433. PMID: 24508166.

4.Deng, L., Kabeche, R., Wang, N., Wu, J.Q., and Moseley, J.B. (2014). Megadalton node assembly by binding of Skb1 to the membrane anchor Slf1.Molecular Biology of the Cell25, 2660-2668. PMID: 25009287.

5.Deng, L., and Moseley, J.B. (2013). Compartmentalized nodes control mitotic entry signaling in fission yeast.Molecular Biology of the Cell24, 1872-1881. PMID: 23615447.