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地址：深圳市光明区光侨路高科创新中心
电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
Mao Li, Ph.D./
Institute/Center
Institute of Chemical Biology
Email
limao(at)szbl.ac.cn
Research Direction
Chemical Biology,Pharmacology,Chemistry
Homepage Link
Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2022 - Present
ShenZhen Bay Laborotary
Junior Principal Investigator
2017 - 2022
ETH Zurich
Post-Doctoral Fellow
2012 - 2016
University of Duisburg-Essen
PhD
2005 - 2012
NanKai University
Bachelor, Master
Research Areas
The main research focuses of the group are: 1. Discovery of small molecules that could target specific nucleic acids; 2. Construction of novel gene delivery systems; 3. Artificial receptors for carbohydrate recognition; 4. Functional peptide studies. Our research methodologies span from organic synthesis, peptide synthesis, molecular recognition to cell biology studies.
Highlights
Utilizing peptidic scaffolds and combining chemical modification strategies, we have developed several highly efficient peptide-based vectors for gene delivery and constructed highly selective artificial receptors for cyclic dinucleotide recognition and carbohydrate recognition.
Honors
Faculty Prize for Best PhD Thesis (2016, University of Duisburg-Essen, Germany)
TEDA-KaiLaiYing Award (2010, Nankai University, China)
Media
Recruitment
Papers
1.M. Li, R. Puschmann, A, Herdlitschka, D. Fiedler, H. Wennemers;Delivery of myo-inositol hexakisphosphate to the cell nucleus with a proline-based cell penetrating peptide;Angew. Chem. Int. Ed.2020, 59,15586(hot paper).
2.M. Li,M. R. Stojković, M. Ehlers, E. Zellermann, I. Piantanida, C. Schmuck; Use of an Octapeptide–Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular β‐Helix that Self‐Assembles into pH‐Responsive Fibers;Angew. Chem. Int. Ed.2016, 55,13015.
3.M. Li, M. Ehlers, S. Schlesiger, E. Zellermann, S. K. Knauer, C. Schmuck; Incorporation of a Non‐Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection;Angew. Chem. Int. Ed.2016,55, 598.
4.M. Li,S. Schlesiger, S. K. Knauer, C. Schmuck;A Tailor‐Made Specific Anion‐Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery;Angew. Chem. Int. Ed.2015,54, 2984.
5.M. Li,S. Schlesiger, S. K. Knauer, C. Schmuck;A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery;Org. Biomol. Chem.2018,16, 2312.
Contact
Address: Gaoke Innovation Center,Guangming District, Shenzhen
Phone: +86-755-86967710
Email: webmaster@szbl.ac.cn
Postal Code: 518132
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