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地址：深圳市光明区光侨路高科创新中心
电话：+86-755-86967710
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电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
Xiaoyu Tang, Ph.D./
Institute/Center
Institute of Chemical Biology
Email
xtang(at)szbl.ac.cn
Research Direction
Chemical Biology,Microbiology,Pharmacology
Homepage Link
Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2020 - Present
Shenzhen Bay Laboratory
Junior Principal Investigator
2018.09 - 2020
Ginkgo Bioworks
Research Scientist
2017.03 - 2018.08
J. Craig Venter & Scripps Institution of Oceanography
Joint Postdoctoral Fellow
2013.11-2017.02
Scripps Institution of Oceanography & Skaggs School of Pharmacy and Pharmaceutical Sciences
Postdoctoral Fellow
2009.12 - 2013.08
University of Tübingen (German Excellence University)
PhD
2006.09 - 2009.06
Nanjing University of Technology
MSc
2002.09 - 2006.06
China Pharmaceutical University
Bachelor
Research Areas
Genetically encoded organic molecules are the common chemical language that unites all life, from single cells to communities of organisms. As natural products, they are broadly applied in medicine, agriculture and nutrition. Our research interests are mainly to discover natural products from the marine bacteria and the human microbiota, decipher their biosynthetic enzymes, and interrogate their biological roles. We are using a combination of genetics, genomics, chemistry, biochemistry, and bioinformatics to answer basic biological questions and to develop new therapeutics.
Highlights
Xiaoyu Tang is an Assistant Professor in the Institute of Chemical Biology at Shenzhen Bay Laboratory. Dr. Tang received his Ph.D. in Pharmaceutical Science from the Eberhard Karls University of Tübingen (Germany). Dr. Tang did his post-doctoral training with Prof. Bradley S. Moore at the Scripps Institution of Oceanography at UCSD and JCVI. Before joining SZBL, he was a Scientist at the leading synthetic biology company Ginkgo Bioworks in Boston. He is a recipient of the 2014 PHOENIX Pharmaceutics Science Award. Over the years, he has developed numerous genome mining techniques that are now standard in the biosynthetic community. His laboratory@SZBL employs a multidisciplinary approach to identify and characterize small molecules from microbes, with an emphasis on the marine and human associated bacteria. As of May 2021, Dr. Tang has published a total of 24 manuscripts, which, according to Google Scholar, have been cited about 570 times. He has been a young editorial board member for the journalChinese Journal of Natural Medicines.
Highlighted in theNature Chemical BiologyNews&Views "Biosynthesis: A sulfonate relay revealed"
ChemBioChemCover Story,ChemBioChemReaders’ Choice 2019
Highlighted in the news ofC&EN“Bacteria behind tooth decay make antibiotics that take out their competitors”
Honors
Rising Star in Biological, Medicinal, and Pharmaceutical Chemistry (ACS Au ) 2026
PHOENIX Pharmaceutical Science Award 2014
“Tübingen Antibacterial Agents” Graduate Fellowship, 2009-2012
Distinguished Master Thesis Award in Jiangsu Province, China, 2010
Media
Recruitment
Papers
1. G. Liao, R. Sun, Z. Shen, Z. Luo, C. Pang, A. Wei, C. Mi, G. Wu, Y.-X. Li, F. F. Li, K. K. HOI*, X. Pan*, X. Tang*. Functional repurposing of a thiolase complex enables Friedel–Crafts acylation in antibiotic biosynthesis. Nature Communications, DOI: 10.1038/s41467-026-68910-6
2. Z. Cheng, B.B. He, K. Lei, Y. Gao, Y. Shi, Z. Zhong, H. Liu, R. Liu, H. Zhang, S. Wu, W. Zhang*, X. Tang*, Y. X. Li*. Rule-based omics mining reveals antimicrobial macrocyclic peptides against drug-resistant clinical isolates. Nature Communications, 2024, 15(1), 4901
3. X. Wang, N. Chen, P. Cruz-Morales, B. Zhong, Y. Zhang, J. Wang, Y. Xiao, X. Fu, Y. Lin, S. Acharya, Z. Li, H. Deng, Y. Sun, L. Bai, X. Tang*, J.D. Keasling*, X. Luo*. Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis. Nature Metabolism, 2024, 6, 933–946
4. H. Zhang, X. Li, S. Huang, M. Cai, W. Shi, M. Liang, Y. Lin, J. Shen, M. Sui, Q. Lai, J. Dou, Z. Shao, X. Luo, Y. Ge*, X. Tang*. A semisynthesis platform for efficient production and exploration of didemnin-based drugs. Angewandte Chemie International Edition, 2024, 63(12), e202318784
5. X. Zou, Z. Hui, R.A. Shepherd, S. Zhao, Y. Wu, Z. Shen, C. Pang, S. Zhou, Z. Yu, J. Zhou, B.S. Moore, L.M. Sanchez, X. Tang*. Unveiling a CAAX protease-like protein involved in didemnin drug maturation and secretion. Advanced Science, 2024, 11(4), e2306044
Contact
Address: Gaoke Innovation Center,Guangming District, Shenzhen
Phone: +86-755-86967710
Email: webmaster@szbl.ac.cn
Postal Code: 518132
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