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地址：深圳市光明区光侨路高科创新中心
电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
电话：+86-755-86967710
邮箱：webmaster@szbl.ac.cn
Yang Chen, Ph.D./
Institute/Center
Institute of Neurological and Psychiatric Disorders
Email
yang.chen(at)szbl.ac.cn
Research Direction
Neuroscience, Physiology, Neurotechnology
Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2024-2026
Technical University of Munich
Junior Group Leader
2018-2023
Technical University of Munich
Postdoc
2013-2018
Technical University of Munich
Ph.D
2008-2012
Fudan University
M.S
2004-2008
Northwest A&F University
B.S
Research Areas
Synaptic and circuit mechanisms of sensory information processing, learning, and memory
Highlights
Dr. Yang Chen’s research focuses on the synaptic and circuit mechanisms underlying sensory information processing, learning, and memory. He addresses these questions by developing high-precision in vivo deep-brain imaging systems and collaborating on developing novel genetically encoded fluorescent biosensors, and has obtained two representative achievements. First, reconstructing at single-synapse resolution the complete input map of layer 4 neurons in the primary visual cortex, providing decisive in vivo evidence for the Hubel-Wiesel feedforward model and an answer to the sixty-year scientific debate. Second, co-developing the world's most sensitive genetically encoded glutamate sensors, enabling neurotransmitter imaging at deep single synapses in living mammals. These results were published as first (including co-first) or co-author in top journals, including Science, Nature Methods (3 papers), and PNAS.
Honors
Media
Recruitment
Papers
1. Chen, Y.*, Kloos, M.*, Varga, Z., Zhang, Y., Piro, I., Sato, T. K., Sakmann, B., Nelken, I., & Konnerth, A. (2026). Thalamic activation of the visual cortex at the single-synapse level. Science, 391(6792), 1349–1354.
2. Aggarwal, A.*, Negrean, A.*, Chen, Y.*, Iyer, R.*, Reep, D., Liu, A., Palutla, A., Xie, M. E., MacLennan, B. J., Hagihara, K. M., Kinsey, L. W., Sun, J. L., Yao, P., Zheng, J., Tsang, A., Tsegaye, G., Zhang, Y., Patel, R. H., Arthur, B. J., … Podgorski, K. (2025). Glutamate indicators with increased sensitivity and tailored deactivation rates. Nature Methods, 23(2), 417–425.
3. Aggarwal, A., Liu, R., Chen, Y., Ralowicz, A. J., Bergerson, S. J., Tomaska, F., Mohar, B., Hanson, T. L., Hasseman, J. P., Reep, D., Tsegaye, G., Yao, P., Ji, X., Kloos, M., Walpita, D., Patel, R., Mohr, M. A., Tillberg, P. W., Looger, L. L., … Podgorski, K. (2023). Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission. Nature Methods, 20(6), 925–934.
4. Zhang, Y., Chen-Engerer, H.-J., Zhang, K., Zott, B., Varga, Z., Chen, Y., Chen, X., Jia, H., Sakmann, B., Nelken, I., & Konnerth, A. (2025). Amyloid β–dependent neuronal silencing through synaptic decoupling. Proceedings of the National Academy of Sciences, 122(35).
Contact
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