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地址:深圳市光明区光侨路高科创新中心
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Yun Ge, Ph.D./
Institute/Center

Institute of Chemical Biology

Email

geyun(at)szbl.ac.cn


Research Direction

Chemical Biology, Glycobiology

Timeline
Areas
Results
Honors
Media
Recruitment
Papers
Timeline
2022 - Present
Shenzhen Bay Laboratory

Junior Principal Investigator

2018 – 2021
Department of Chemistry and Chemical Biology, Harvard University

Postdoctoral Fellow

2013 – 2018
Peking University

Ph.D. in Chemical Biology

2009 – 2013
Xiamen University

B.Sc. in Chemistry

Research Areas

Glycan code is fundamental to molecular interactions and information flow in living systems. However, unlike the genome and proteome, the glycome still represents an uncharted frontier. Focusing on glycan interactions and modifications, our lab aims to build a profile–edit–engineer paradigm across the glycan–protein and glycan–RNA axes to achieve programmable control across scales and convert mechanistic and functional understanding into controllable and deployable solutions for the regulation of cellular activities and disease.

Our research interests lie in three directions:

(1)PreciseGlycan Editing:Along the glycan–protein and glycan–RNA axes, we develop spatiotemporally resolved, substrate-selective glycan-editing and interface-rewiring tools to enable precise interventions in defined cellular contexts.

(2)In-depth Glycan Function Decoding:Using an interdisciplinary chemical biology toolkit, we interrogate the crosstalk between glycans and proteins/RNA, emphasizing space- and state-specific functions—e.g., at the cell surface and within biomolecular condensates—and link condensates and transcription/translation programs.

(3)Glycan-Enabled Translational Applications:We uncover glycan-coassembled functional microenvironments and design systematic profiling and intervention strategies for diagnosis and therapy—including glycan editing to boost cancer immunotherapy, discovery of new cell-surface markers and glycan-mediated interactions, and glycan-empowered biodrugs.

Highlights

Yun Ge is a junior PI at the Institute of Chemical Biology, Shenzhen Bay Laboratory, and an assistant professorat Peking University Shenzhen Graduate School. She is a recipient of the National Natural Science Foundation of China Excellent Young Scientists Fund (Overseas)and several other national grants. Dr. Ge received her B.S. from Xiamen University in 2013 and her Ph.D. from Peking University in 2018, followed by postdoctoral training in the Department of Chemistry and Chemical Biology at Harvard University. She joined SZBL in 2022 to establish her independent laboratory.

The Ge Lab focuses on the chemical biology of glycan interaction and editing. Current efforts center on (i) profiling glycosylation and developing precision glycan-editing tools, (ii) uncovering the unique roles of glycosylation across diverse biological systems, and (iii) empowering functional biomolecules with glycan modifications for therapeutic applications.

As first or corresponding author, Dr. Ge has published in Nature Cell Biology, Nature Chemical Biology, Nature Communications, Journal of the American Chemical Society, and Angewandte Chemie etc.. She holds several international and domestic patents and was invited by Cell on its 50th anniversary to comment on future directions in glycobiology. Major achievements in the Ge lab include: developing the first protein-selective “eraser” of glycosylation for precise functional dissection; establishing regulatory principles of glycosylation in biomolecular condensates and creating tools to modulate processes such as stress-granule dynamics; building a nanobody glycoengineering platform to enable glycan-based cancer immunotherapy strategies; and establishing systematic surfaceome profiling and intervention technologies for cell-membrane proteins.


Honors
2013 – 2015 Presidential Fellowship for Ph.D. Students, Peking University
2016 Tang Aoqing Chemistry Scholarship
2017 CHINA National Scholarship for Graduates
2018 Outstanding Graduates Award, Peking University
Recruitment
Papers

[1] N. Wang, F. Hou, S. Ma, S. Liu, H. Wei, W. Fang, K. Zhang, YGe*,“Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase”Nat. Commun. 2025, in press.

[2] S. Sun, S. Liu, T. Deng, Y. Hu, R. Yang, J. P. Li*, Y. Ge*, “Cocktail Chemical Labeling for In-Depth Surfaceome Profiling of Bone-Marrow-Derived Dendritic Cells”Anal. Chem. 2025, acs. analchem. 5c02734.

[3] J. Wu#, H. Lu#, X. Xu, L. Rao*,Y. Ge*, “Engineered Cellular Vesicles Displaying Glycosylated Nanobodies for Cancer Immunotherapy”AngewChemIntEd202463, e202404889.

[4] Peter H. Seeberger, Yun Ge, Christine M. Szymanski, Daniel Kolarich, Morten Thaysen-Andersen, Nicolle H. Packer, Elisa Fadda, Benjamin Davis, Shoko Nishihara, Gabriel A. Rabinovich, Peter D. Kwong, Richard Strasser, “What comes next in glycobiology” Cell 2024, 187, 2628–2632.

[5] Y. Liu#, Y. Ge#, R. Zeng#, W. S. C. Ngai, X. Fan, P. R. Chen*, “Proximity Chemistry in Living Systems”CCS Chem20235, 802–813.

[6] Y. Chen#, R. Wan#, Z. Zou#, L. Lao, G. Shao, Y. Zheng, L. Tang, Y. Yuan,Y. Ge*, C. He*, S. Lin*, “O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins”NatCell Biol202325, 1676–1690.

[7] Y. Ge, D. H. Ramirez, B. Yang, A. K. D’Souza, C. Aonbangkhen, S. Wong, C. M. Woo*, “Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase”NatChemBiol202117, 593–600.

[8] Y. Ge#, L. Chen#, S. Liu, J. Zhao, H. Zhang, P. R. Chen*, “Enzyme-Mediated Intercellular Proximity Labeling for Detecting Cell–Cell Interactions”J. Am. Chem. Soc. 2019141, 1833–1837.