The Institute of Systems and Physical Biology of Shenzhen Bay Laboratory is dedicated to basic biomedical research, focusing on fundamental systems biology challenges by interdisciplinary collaborations broadly covering genomics and epigenetics, protein drug design, protein engineering and enzyme catalysis, signal transduction, bioinformatics and artificial intelligence, metabolic control, and photobiology. Systems biology integrates computational methods, e.g., molecular dynamics simulations and mathematical modeling, with biophysical and biochemical experiments, and different high-throughput omics techniques to investigate structure-function relations of living organisms at systems level, in order to unveil the underlying principles that are difficult to study in the traditional biological research.