October 24-26, 2025, the “2025 Symposium on Frontiers in Computational Chemistry, Biophysics, and Bioscience” was held at the Shenzhen Medical Academy of Research and Translation (SMART). Initiated by Chen Song (Peking University), Yuji SUGITA (RIkagaku KENkyusho, Japan), and Wonpil IM (Lehigh University, USA), this annual conference series rotates among China, Japan, and South Korea. It aims to foster regional and international academic exchange and collaboration, particularly by providing young scientists with an international platform for showcasing their work. This edition focused on cutting-edge interdisciplinary approaches at the intersection of computational chemistry and experimental biophysics, discussing the latest methodological developments and frontier research directions within the field. The conference featured 19 speakers from China, 9 from Japan, 8 from South Korea, and multiple participants from research institutions in the United States, Australia, Singapore, and Europe, fostering interdisciplinary intellectual exchange and cross-regional academic collaboration. 

Organized by SMART, the organizing committee comprised Chen Song (Peking University), Yaoqi Zhou (Shenzhen Bay Laboratory), Yuji SUGITA (RIkagaku KENkyusho, Japan), Wonpil IM (Lehigh University, USA), Yi Wang (The Chinese University of Hong Kong), Guowei Yin (Sun Yat-sen University), and Chang Yun SON (Seoul National University, South Korea). The conference featured 41 presentations across four major themes: computational biophysics, experimental biophysics, artificial intelligence and protein design, and structure-based drug design. Topics encompassed complex biomembrane systems, structural-functional regulation of biomacromolecules, liquid-liquid phase separation, multiscale simulation methods, novel approaches to structure prediction and characterization, innovative drug design, and studies on drug mechanisms of action.

The presentations were captivating, sparking vigorous discussions. Beyond invited talks, the conference provided selected postdoctoral researchers and graduate students with opportunities to deliver oral presentations. Additionally, a poster session featured 18 posters on display. Among these, posters by Tadsanee Awang, Lianxin Wang, and Yajing Qi were honored with the Best Poster Awards, presented by the Chinese organizing committee and keynote speakers during the closing ceremony.

During the conference, attendees toured SMART, expressing admiration for its worry-free research environment. At the conclusion, all participants highly praised the event, fully affirming its success in fostering interdisciplinary and cross-regional exchange.