Obesity and obesity-related metabolic disorders have been major challenges for physical fitness. People’s desire to eat a variety of delicious food is leading to increasing high-fat diet (HFD) that will cause damage to human health, especially causing metabolic and chronic illnesses.

Recently, researchers from SZBL, Chongqing University, Institute of Neuroscience(CAS) and Zhejiang University had co-published a paper, “High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila” on eLife, which explores a mechanism that links HFD, neuronal autophagy, and starvation-induced hyperactivity, shedding light on the reshaping of neural circuitry under metabolic challenges and the progression of metabolic diseases.

HUANG Rui, guest researcher of SZBL and also researcher from Chongqing University, SONG Tingting, research associate of SZBL and SU Haifeng, assistant researcher of SZBL, serve as co-first authors of the published paper. The study was instructed by Professor WANG Liming from Zhejiang University.

To find out more about the study, please access:

https://elifesciences.org/articles/53103

DOI：http://10.7554/eLife.53103